Penambatan Molekuler Penghambatan Aktivitas Enzim α-Amilase dan α-Glukosidase oleh Senyawa Aktif Daun Kirinyuh (Chromolaena odorata L.)

An in silico study was conducted to inhibit the active compound Kirinyuh leaves (Chromolaena odorata L.) against α-amylase and α-glucosidase enzymes using a molecular docking approach. The carried out on 19 compounds that had been identified were optimized PM3 method. best results of enzyme shown by from flavanone group, namely genkwanin sakuranetin with binding affinities -8.3 kcal/mol -8.1 kcal/mol, respectively, while inhibiting two hydroxybenzoic acid p-coumaric p-hydroxybenzoic bond -5.7 kcal.mol -5.5 kcal.mol, respectively. interaction between produces one conventional hydrogen GLU 233 GLN 63 three bonds, HIS 112; 182; ASP 352 GU 277; 279; 352.